How to start an essay introduction? When you start writing an essay, you write an introduction first. Its mission is to present your viewpoint on the topic you are about to cover. Although it sounds pretty simple, it is actually quite tricky. It may take time and effort to create a brief, informative, and captivating paragraph that will encourage the reader to check the rest of the essay.This article provides you with relevant writing essay introduction tips, steps and examples for your reference.

一.how to start an essay introduction

An introduction of an essay is your abstract plan for the whole essay. A good welcoming paragraph serves two strategic functions. Firstly, it informs the reader about the essay topic and gives some explanation to the major idea. Secondly, it encourages the reader to check the rest of your essay. Thanks to a well-written introduction, you will make your work’s “first impression” positive. No need to say how crucial it is! Your first words determine the tone of the further content. It will make your reader involved right from the very beginning.

一篇文章的導言是你對整個文章的抽象計劃。一個好的歡迎段落有兩個戰略作用。首先，它告訴讀者文章的主題，并對主要思想給出一些解釋。其次，它鼓勵讀者檢查你的文章的其余部分。多虧了一篇寫得很好的介紹，你的作品會給人留下積極的“第一印象”。不用說這有多重要!你的第一個詞決定了后面內容的基調。這會讓你的讀者從一開始就參與進來。

Regardless of the general size of your essay, the introduction shouldn’t be too long. If you are writing a brief personal essay that follows the standard structure, you may limit the introduction to a single paragraph. If you are writing an extensive research essay, you can have just several paragraphs in the welcoming section. Ideally, you should make it cover around 8% of the total length.

二.how to start an essay

How to start essay from scratch? What needs to be done to create a worthy piece of content? Here are several useful tips to be followed:

如何從零開始寫文章?需要做什么才能創造出有價值的內容?以下是一些有用的建議:

1.Know your topic

Before you start writing an introductory paragraph, conduct thorough research on the selected topic. Without knowing what you want to write about, you won’t be able to create something worthy. You need to know as much as possible about your topic to express the right opinion to the reader.

2.Conduct the research

It is hardly possible to trust your personal knowledge if you don’t have sufficient expertise in the field you are writing about. Doing through research will help you make your thesis statement. And it will also guide you in outlining the content of your essay. So, be careful with the details that you are adding to your introduction. Make sure that they are relevant to the main topic of your narration.

如果你在你所寫的領域沒有足夠的專業知識，你幾乎不可能相信你的個人知識。做研究將有助于你的論文陳述。它也會指導你概述文章的內容。所以，要注意你在介紹中添加的細節。確保它們與你的敘述主題相關。

3.Set the tone of narration

Whether you want to lead the narration in a formal or informal way, you will need to set the tone at the very beginning. Formal writing will have a polite and emotionless tone because the focus is set on facts themselves. Meanwhile, informal writing will be filled with emotions due to the integration of “fancy” words, slang, and figures of speech. The tone of an introduction will determine the format of relationship between you and your reader.

4.State the purpose and frame up the context

A good introduction indicates the context and direction for the reader. It explains why you are writing about the topic, and what you are going to achieve with it. This way, you show why your essay is worth the reader’s attention.

好的導言為讀者指明了背景和方向。它解釋了你為什么要寫這個主題，以及你要用它達到什么目的。這樣，你就顯示了為什么你的文章值得讀者關注。

5.Express a clear point of view

An introduction must demonstrate your attitude to the specific topic. You must mention your thoughts and opinions, as well as your personal feelings about the subject matter. Ideally, a well-written introductory paragraph should do this in a single sentence, namely a thesis statement. It’s reasonable to put your main statement at the beginning or the end of the introductory paragraph. As the practice shows, an average reader pays most attention to these parts.

6.Lead the reader throughout the narration

The reader should be guided throughout the essay. And your goal is to be his/her guide by explaining what to expect in the body of your essay. By mentioning the major ideas and thoughts in the introduction, you will let the reader focus on them in the following paragraphs.

整篇文章都應該引導讀者。你的目標是成為他/她的向導，通過解釋你的文章的主體部分。通過在引言中提到主要的觀點和想法，你將讓讀者在接下來的段落中關注它們。

三．essay introduction example

Prompt:The title of this essay is:Genome Sequencing: Its Introduction, Types, Uses, And Its Impact On Human Life.This is a complete article to help you understand the role of the introduction

Introduction

Sequencing is the arrangement of nucleotides. It includes different technologies that are used to arrange or know the arrangement of adenine, guanine, cytosine and thymine. It is used for molecular study of genomes and protiens that are encoded. Information that’s obtained by sequencing help us to understand the changes in genome of an organism. Even by sequencing we can understand the effect of phenotypes on genome.

DNA sequencing technique is also known as electrophoresis. It separates the pieces of DNA that are different in length one by one. In this technique the DNA that is supposed to be sequenced is present at the end of the gel. Gelatin type substance runs down. Gel contains electrodes when current is provided the molecules move. Smaller molecules move rapidly while larger molecules take time in this way DNA molecules are separated.

TYPES OF GENOME SEQUENCING

There are different types of genome sequencing. Just by focusing on very specific areas of DNA the whole genome can be sequenced. Names of different types of sequencing are given below.

Whole genome sequencing

De novo sequencing

Targeted genome sequencing

Exome pulldown

Whole Genome sequencing:

It is the process of determining the complete sequence of DNA of any kind of organism at a single time. In this type sequence of chromosomal DNA and mitochondrial DNA are obtained at the same time. Basic purpose is to map out the uniqueness of DNA of a specific person. A doctor or a genetic counsellor can do it if patient is suffering from genetic disorder. It can be used for different purposes.

It can be used in agriculture.

It can be used in Public health

This technique is so versatile. It can be used in variety of settings and variety of different reasons. With whole genome sequencing we can identify what kind of pathogen is present within a specific person or a specie. Even with the help of this sequencing we can identify that what kind of bacteria can effect human beings to what extent. In the given diagram process of whole genome sequencing is shown

DE NOVO SEQUENCING

De novo is a Latin word which means again or anew. It is a form of peptide sequencing that is performed without prior knowledge of amino acids sequence. This method can obtain the sequence without protein databases. It can overcome the limitations of data base dependent methods like peptide mass fingerprinting. In addition it can be used for un sequenced organisms antibodies and peptides with post translational methods.

This is the type of sequencing when the whole genome is sequenced for the 1st time without having REFERENCE GENOME. It is typically accomplished by arranging whole genome in such a way that it can be read a full sequence. They yield a primary genetic sequence of a particular organism if the data is not previously available.

Targeted genome sequencing

As it is clear from its name that targeted genome sequencing basically focus on a targeted area of interest within the genome.

There are many purposes for which targeted genome sequencing is used one of them is to find ‘single nucleotide polymorphisms’. They bring the most common type of variations within the organism so by gaining the knowledge about snps it will be easy for the scientists to recognize the diseased gene.

During targeted genome sequence the amplification of gene of interest is done. This process of amplification is called polymerase chain reaction. After amplification the high throughput sequencing is done. Time needed for sequencing process is reduced by this method. It allows for more in depth studies of region of genome.

Different focused panels are made so that they can study about those genes that are associated with diseases.

Exom Pulldown

Exom pulldown sequencing is a type of targeted sequencing. Targeted sequencing is basically defined as the type in which the researchers focus only on the specific areas within a genome. In case of exom pulldown sequencing, the researchers focus only on the genes of genomes. The exomes contain all the instructions and information needed to make protein in our body. Also the sequencing in an exome is much more cheaper as compared to sequencing the whole genome. In this type of sequencing, the scientists only focus on a small part of the genome so it helps them to focus completely on the parts of the DNA sequence which is more likely to be linked with the disease. But the comes a fact that the exom sequencing is only able to focus on the variants of coding regions that mainly affects the protein function. It is not able to study the non-coding variants that can be related to the disease so for this purpose whole genome sequencing is more suitable.

USES

Many cancer sequencing schemes has helped the doctors by providing the catalogue of somatic mutations. E.g TCGA, ICGC. Most of these kind of projects have both exom and whole genome sequencing elements. So sequencing is very useful to know mutation pathways

Family data base studies are also available so we can understand certain genetic disorders that run through generations. This might seem like old fashion but helping people to combat many diseases. With a large family pedigree you can link the mutations with the history of patient

Now medicines can also be personalized. Just by using SNP arrays many pharmacogenomics projects are on their way

WGS is even very important for the clinical trials. As by knowing the family history before we can easily implement s specific medicine on the group of interest.

Samples of well phenotype cohorts was one of the basic need of genetic studies. Overtime many of these cohorts or interests are grown in number because of sequencing.

IMPACT ON HUMAN LIFE

Impact of Genome Sequencing on Human Life:

Genome sequencing is a technology that has taken the world by storm. It has made many impacts on human life since it has been started. It has positive and negative aspects as well.

POSTIVE IMPACTS

We are aware of the worldwide outbreak of Severe Acute Respiratory Syndrome (SARS). It has affected many people till date. Its origin was not known. Doctors didn’t know the reason of its spread. After that, this virus was studied in detail and its genome was sequenced. The information that the biotechnologists got from its sequencing was quite valuable. They got to know its origin. It also helped in the diagnosis of the disease. This has made a great impact on mankind as well as the technology.

Now humans have better understanding of different viruses and the diseases and now they can treat those diseases by using all the information they have got by genome sequencing.

Genome sequencing has helped to form many things that are of great commercial use hence providing humans with more benefits. The sequencing has helped us to find new growth factors, hormones that were undiscovered before and immunity mediators.

By studying the sequence of different genomes, we can reach the depth of that particular organism whose genome is being studied and this can help us to change it the way we want and in this way GMOs come into existence that are making our life better. For example, cows with more milk production, vegetables with attractive colours and great taste, fruits that are more juicy and tasty, all of this has become possible because of this technology.

Great medicines and great agriculture is the promise of genome sequencing for humans. As we get more information about the sequence of the genome of different organisms, we are more likely to make them better and mould them according to our needs.

The Human Genome Project has made a huge economic impact and its success has earned great amount of money for the workers.

Genome sequencing has made a great impact as it can help to treat rare and inherited diseases. Moreover, it can inform us about a man’s risk of developing and having a disease and his response towards the treatment.

NEGATIVE IMPACTS

The process of genome sequencing is very complexed. It must be made sure that the sequence has been read carefully and with high accuracy. A wrong sequence can change the whole information and then it can change the whole process of developing medicines and treatments and can have a bad impact on everyone.

基因組測序的過程非常復雜。必須確保序列已經被仔細地閱讀，并且具有很高的準確性。一個錯誤的序列可以改變整個信息，然后它可以改變開發藥物和治療的整個過程，可以對每個人產生不好的影響。

Genomic sequencing can unveil such kind of information that can affect a person and his family psychologically. For example, sometimes such condition can occur that causes indecisiveness in the patient and his family regarding their health conditions.

Another negative impact of genome sequencing is that it can cause discrimination that is based upon genetic information among different people. The process of genome sequencing needs a lot of human and computer resources that requires a huge investment and can be quite troublesome for many developing countries.

CONCLUSION

I conclude that gene sequencing has helped us in many ways and we can gain more benefit from it if it is less expensive.

If you are not sure how to present your topic, you can start an essay by writing the body paragraphs. Once you are done with them, you will come back to the introduction. This approach is quite popular among students because it allows them to understand where an essay goes before they come up with an introduction for it.

如果你不確定如何表達你的主題，你可以通過寫主體段落來開始一篇文章。一旦你完成了它們，你會回到介紹。這種方法在學生中很受歡迎，因為它可以讓他們在構思一篇文章的介紹之前了解文章的走向。

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